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注册即领取38元体验金 > 富氢水的作用>>国际著名心血管病学者Jan Slezak教授

国际著名心血管病学者Jan Slezak教授

来源:开户送38体验金不限id 编辑:James&Ani 时间:2017-09-16 14:18:07

Jan Slezak教授,斯洛伐克杰出科学家和心脏病专家。1940年5月24日出生在布拉迪斯拉发。布拉迪斯拉发是斯洛伐克共和国首都和经济文化中心,西斯洛伐克州的首府,也是斯洛伐克最大的城市。1963年毕业于布拉迪斯拉发Comenius大学医学院,随后加入斯洛伐克科学院实验外科学所攻读研究生学位,这个研究所后来称为心脏病研究所(IHR) SAS。1968年,他获得博士学位,并建立了自己的实验室,后来他在该研究所多年担任电镜和组织化学实验室主任。

 

JanSlezak教授一直围绕该研究所的工作任务开展研究,1976年被任命为研究所副所长,1988年被任命为所长,1998年当选为该研究所学术主席团成员和副主席,在这个位置上直到2009年6月,由于他的出色组织管理能力,斯洛伐克医科大学邀请他担任副校长。

JanSlezak教授主要研究兴趣集中在实验心脏病学功能形态学方向,尤其是关于心肌缺血、心肌肥大、非均质性和预适应等方面。他系统研究了活性氧在心脏损伤发生中的作用机制,对辐射诱发心脏病预防和缺血性预处理等也开展了深入研究。

在他的科学生涯中,先后发表550篇学术论文,10本专著和5本教科书。受到许多国际学术机构邀请在国际会议上做学术报告,先后访问大量著名学术机构。他也是一些著名研究机构和大学的董事会成员,9本学术期刊编辑委员会成员。他一直担欧洲心脏研究委员会委员和国际心血管科学院和董事会成员。由于他在科学研究和教育方面的突出贡献,被先后授予许多重要奖项。

非常重要的是,著名的JanSlezak教授已经参与了氢气治疗放射性损伤保护的研究

9月15日他给广州氢医学十周年带来的学术报告题目是:本人有幸给他做简介。

Therapeutic applicationof molecular hydrogen in situations with excessive production of free radicals

Ján Slezák1, Juraj Surový2, Ján Buday2,Branislav Kura1

1Institute forHeart Research, Slovak Academy of Sciences, Bratislava, Slovakia

2ElectrotechnicalResearch and Projecting Company, Nová Dubnica, Slovakia

jan.slezak@savba.sk

BACKGROUND:As a common denominator of many pathological processes, excessive production of reactiveoxygen species (ROS) has been regarded. Hydroxyl andnitrosyl radicals are the major cause of the destruction of biomolecules eitherby a direct action or by triggering the chain reaction of free radicals. Scavengingof excessive levels of ROS may result in preventive or therapeutic effects. A number of substances including molecular hydrogen, can serve as scavengers that increase thecapacity/activity of endogenousantioxidants thereby augmenting cells and tissues protection against oxidative damage.                                                                                                  OBJECTIVES:Targetedapplication of molecular hydrogen (H2) as one of the potentscavengers may be used in the prevention and treatment of ROS-related diseases.H2 reacts with strong oxidants, suchas hydroxyl and/or nitrosyl radicals thatmakesit possible to utilize its potential for preventive and therapeuticapplications. H2 is able to reduce oxidative stress also byregulating gene expression, and acts as an anti-inflammatory and anti-apoptoticagent.                                                                                                 METHODS: As a source of free radicals, we used radiation thatinteracts with the water present in the cells, resulting in its hydrolysis andformation of free radicals (especially hydroxyl OH). Wistar rats atthe age of 12 weeks, weighing approximately 250 g, were irradiated with asingle dose of 25 Gy (6-7 Gy / min) and/or 10 Gy (4-5 Gy / min.) targeted to the mediastinal area. Therapeuticapplication of hydrogen has been performed by different delivery methodsincluding inhalation, drinking hydrogen rich water and/or infusion ofhydrogen-saturated solutions.Concentrations of malondialdehyde (MDA) in rat serum were determined byspectrophotometric method using a commercially available TBARS assay kit(Cayman Chemical, Michigan, USA). TNF-α expression was analyzed from the leftventricle tissue using the Western blot method. Changes in miRNA 1, 15b and 21levels were measured byRTqPCR.                                                                                       RESULTS: Theresults demonstrate in irradiated rats a decrease in MDA and TNF-α levels aswell as miRNAs return almost to control levels following H2 administration.

 CONCLUSION: H2 may be an effective and novelclinical tool for treating oxidative stress-related diseases. miRNAsrepresent potential targets for modulation and manipulation to be used asbiomarkers and therapeutic instruments.

Themissing links of how hydrogen is involved in cell signaling and activation orsuppression of transduction pathways, and how molecular hydrogen can reduceinflammation deserve special attention.

  研究结果证明,各种给氢气的方法,吸入、饮用或注射氢水都可以对抗放射线导致的氧化和炎症损伤,这种损伤可以用MiRNA检测进行分析。属于会议摘要,详细研究结果请等待正式发表。

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